Randomized Clinical Trials and Observational Studies
نویسندگان
چکیده
منابع مشابه
Clinical research in anaesthesia; randomized controlled trials or observational studies?
The new millennium has seen a consolidation of the difficulties in pursuing clinical research in anaesthesia. Anaesthesia is rarely seen as a specialty with a high academic profile [1]. Universities have been encouraged to concentrate their research effort on basic sciences, and research in clinical medicine has concentrated on those areas with a large impact on public health. In the UK cancer,...
متن کاملClinical research in anaesthesia; randomized controlled trials or observational studies?
The new millennium has seen a consolidation of the difficulties in pursuing clinical research in anaesthesia. Anaesthesia is rarely seen as a specialty with a high academic profile [1]. Universities have been encouraged to concentrate their research effort on basic sciences, and research in clinical medicine has concentrated on those areas with a large impact on public health. In the UK cancer,...
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CLINICAL EPIDEMIOLOGY AS A DISCIPLINE has evolved rapidly dur ing the last decade. However, application of epidemiotogic principles in surgical clinical research has been limited. In the March 1996 issue of SURGERY we discussed the principles, application, and limitations of randomized clinical trials (RCTs) in surgery. RCTs are often viewed as the gold standard for evaluation of therapeutic ef...
متن کاملA comparison of observational studies and randomized, controlled trials
BACKGROUND For many years it has been claimed that observational studies find stronger treatment effects than randomized, controlled trials. We compared the results of observational studies with those of randomized, controlled trials. METHODS We searched the Abridged Index Medicus and Cochrane data bases to identify observational studies reported between 1985 and 1998 that compared two or mor...
متن کاملAdaptive Matching in Randomized Trials and Observational Studies.
In many randomized and observational studies the allocation of treatment among a sample of n independent and identically distributed units is a function of the covariates of all sampled units. As a result, the treatment labels among the units are possibly dependent, complicating estimation and posing challenges for statistical inference. For example, cluster randomized trials frequently sample ...
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ژورنال
عنوان ژورنال: JACC: Cardiovascular Interventions
سال: 2008
ISSN: 1936-8798
DOI: 10.1016/j.jcin.2008.01.008